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pentobarbital will decrease the extent or impact of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will lower the level or impact of donepezil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.Contraindicated (one)pentobarbital decreases levels of vandet